Engineered gut bacteria therapy can reduce appetite and fight obesity

Engineered gut bacteria therapy can reduce appetite and fight obesity

In a new find, researchers have revealed that gut bacteria therapy can help in reducing weight gain. According to study authors, obesity is the root of several health related problems and it is striking the world with unprecedented force. Thus, in order to curb the obesity and weight gain, researchers have engineered gut bacteria and have found positive results against the disease.

“Some day in the future, it might be possible to treat the worst effects of obesity simply by administering these bacteria,” said lead study author Sean Davies, Associate Professor of Pharmacology at Vanderbilt University in Nashville, Tennessee, US. “Because of the sustainability of gut bacteria, this treatment would not need to be every day.”

For the study, researchers altered the gut bacteria which enabled these microorganisms to produce a small lipid which reduces the appetite and inflammation.

Scientists say that people suffering from obesity tend to produce less amount of this lipid which increases the appetite and causes the inflammatory effect. Due to increased appetite, people tend to eat more which further worsens the situation.

Engineered bacteria produce lipid in the intestine due to which obese eat less, consume lesser amount of calories and fight obesity.

Researchers conducted the study on mice and found that engineered gut bacteria were effective against obesity. What’s striking was that the therapy also helped against those mice prone to atherosclerosis (hardening of the arteries) and fatty liver disease.

It was noted that mice with altered gut bacteria accumulated less fat even if they were fed with excess diet and drank less water. It reduced that risk of developing fatty liver disease and atherosclerosis.

The study is still in its early stages and its effect on humans still needs to be tested. However, it has given new insight into how gut bacteria can help humans in fighting against obesity. Clinical trials will tell whether it can be used effectively on humans or not.

The study was presented at the American Physiological Society’s Inflammation, Immunity and Cardiovascular Disease conference in Westminster, Colorado.

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