According to the new research done at the Salk Institute in San Diego, it has been made clear that protecting the Beta cells can treat diabetes and even more serious diseases like cancer, etc.
The researchers have come across an unexpected component in the Beta cells and the mouse models: Vitamin D. They found this composition along with another compound that helps in activating its receptors. Hence, it is proved that vitamin D is helpful in treating the Beta cells in damaged conditions.
Beta cells help in producing, storing, and releasing insulin in the pancreas. When the Beta cells stop functioning, the body loses its ability to produce insulin that controls blood sugar and glucose levels. When the glucose and blood sugar levels tend to increase in the blood system, it can become dangerous and fatal.
The new research has also provided information about the gene regulation that can be applied in the treatment of other diseases at the same time such as cancer, etc.
While creating the Beta cells from the embryonic stem cells, the researchers came across a compound known as iBRD9 that helps in improving the activation of vitamin D receptor when combined along with Vitamin D. It also shows improvement in the continued existence of the Beta cells.
The senior author of the journal, Ronald Evans said diabetes is a disease majorly caused by severe inflammation. In this study, the researchers have identified the receptor vitamin D to be the crucial modulator for both inflammations as well as the survival of the Beta cells.
According to the researchers, mixing vitamin D with the new compound enabled numerous protective genes to be expressed at the indifferent levels as compared to that of the diseased cells.
There was a screening test done by the team where they investigated the compounds that helped in improving the Beta cells survival in a dish. They also investigated the combination in a diabetic mouse model and the results showed that it can bring back the levels of glucose to normal in animals.
According to the researchers, the new compound does not seem to have any side effects in the mouse model but it cannot be said that it is safe for humans. It requires a lot more testing and clinical trials before proving it helpful for human use.